Nils Metzler-Nolte


Chemistry

2340 Views Medicinal Inorganic Chemistry Lecture 1

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The use of metal ions/complexes in medicinal practice extends into ancient history. Some medical uses were more in the form of magical potions to delay aging or improve virility,however medicinal inorganic chemistry as a discipline has come of age only in the last 30 years since the discovery of the antitumor activity of cisplatin. The field of medicinal inorganic chemistry is expanding and can be roughly divided into two main streams – therapeutic and diagnostic. Chemotherapeutics such as anticancer agents, metal-mediated antibiotics,antibacterials,antivirals antiparisitic,antiarthritis agents are becoming popular. Diagnostic applications of inorganic chemistry are in the rapidly growing field of medical imaging of all types with 99m Tc- and other radiopharmaceuticals used in nuclear medicine being the highlight. In the present course key developments in metal based therapeutic and disgnostic agents,their commercialization,current research directions will be dealt with in detail. These advanced opics will be dealt with in the course for the benefit of M.Sc.,Ph.D and faculty from the department of Chemistry, Savitribai Phule Pune University,its affiliated colleges, other universities and institutions The primary objectives of the course are as follows: 1) Explaining the history,drug discovery pipeline and concepts of metal-based drugs. 2) Detailing the current status,mechanism and development of platinum based anticancer drugs 3) Current research directions using other metal complexes as anticancer,anti-arthritis,anti-diabetes , anti-bipolar disorders

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